²úÆ·ÖÐÐÄ
ÁªÏµÐµÃÀû
ÏúÊÛרÓãº
µØµã£º±±¾©Êк£µíÇøÎ÷С¿Ú·66ºÅÖйش嶫Éý¿Æ¼¼Ô°C-1Â¥Èý²ã
³¤Ð§¶àëÄÖ¬·¾Ëá²àÁ´
ÒȸßѪÌÇËØÑùëÄ-1£¨Glucagon-like Peptide-1, GLP-1£©ÊÇÓÉÈ˳¦µÀÉøÍ¸µÄÒ»ÖÖëÄÀà¼¤ËØ£¬£¬£¬£¬Ëü¿É´Ì¼¤Òȵºβϸ°ûÉøÍ¸ÒȵºËØ£¬£¬£¬£¬¼ÓÈëÌåÄÚѪÌÇÆ½ºâµ÷Àí¡£¡£GLP-1ÊÜÌ弤¶¯¼ÁÒѱ»ÆÕ±éÓ¦ÓÃÓÚ2ÐÍÌÇÄò²¡ºÍ·ÊÅÖµÄÖÎÁÆ¡£¡£
ʹÓÃÖ¬·¾Ëá²àÁ´ÐÞÊÎÊÖÒÕ£¬£¬£¬£¬¿ÉʵÏÖGLP-1ÀàËÆÎïµÄ³¤Ð§»¯£¬£¬£¬£¬¼«´óÌá¸ß»¼ÕßÒÀ´ÓÐÔ¡£¡£Ö¬·¾ËáÄܹ»ÒÔ¿ÉÄæµÄ·½·¨ÓëѪ½¬°×ÂѰף¨human serum albumin£¬£¬£¬£¬HSA£©Á¬Ïµ£¬£¬£¬£¬±£»£»£»£»¤¶àëÄÃâÊÜDPP-IV ½µ½âºÍÉö¹ýÂË£¬£¬£¬£¬´Ó¶øÑÓÉìÒ©Îï°ëË¥ÆÚ¡£¡£
ÏÖÔÚÊг¡Ö÷Á÷³¤Ð§GLP-1ÊÜÌ弤¶¯¼Á£¬£¬£¬£¬ÈçÀûÀ³ëÄ£¨Liraglutide£©¡¢Ë¾ÃÀ¸ñ³ëÄ£¨Semaglutide£© ºÍÌæ¶û²´ëÄ£¨Tirzepatide£©,¾ù½ÓÄÉÖ¬·¾Ëá²àÁ´ÐÞÊÎÊÖÒÕ¡£¡£

Fig 1˾ÃÀ¸ñ³ëĺÍÌæ¶û²´ëĽṹ
Fig 1 The Structure of Semaglutide and Tirzepatide
еÃÀû¿Æ¼¼¿ÉÌṩʵÑéÊÒ¼°GMP¼¶±ðµÄ¸ßƱðÀ묷¾Ëá²àÁ´²úÆ·£¬£¬£¬£¬Æä׿ԽµÄ´¿¶ÈºÍ´ó¹æÄ£µÄÉú²úÄÜÁ¦£¬£¬£¬£¬È·±£Á˲úÆ·µÄÒ»ÖÂÐԺͿɿ¿ÐÔ£¬£¬£¬£¬µ¥Åú´Î²úÁ¿¿ÉµÖ´ï10¹«½ï£¬£¬£¬£¬²¢¿ÉÀ©Õ¹ÖÁ100¹«½ï£¬£¬£¬£¬Öª×ãÄú´ÓÔçÆÚÒ©ÎïÑз¢µ½ÉÌÒµ»¯Éú²úÈ«Á÷³ÌµÄÐèÇ󡣡£
¹«Ë¾³Ð¼Ì“ÒÔÖÊÁÏÁ¢ÒìÒýÁìÉúÎïÒ½Ò©Á¢Ò씵Ä×ÚÖ¼£¬£¬£¬£¬×¢ÖØÊÖÒÕÑз¢£¬£¬£¬£¬ÈçÄúÐèÒªÆäËüδÁгöµÄ½á¹¹£¬£¬£¬£¬½Ó´ýÄúÀ´µç×Éѯ£¬£¬£¬£¬ÐµÃÀû¿Æ¼¼¿ÉÌṩ²àÁ´Àà²úÆ·µÄ¶¨ÖƺϳÉЧÀÍ£¬£¬£¬£¬ÎªÄúµÄÑз¢ÏîÄ¿ÌṩÖÜȫ֧³Ö¡£¡£
ÐòºÅ
Æ·Ãû
´úºÅ
½á¹¹Ê½
´¿¶È
+